SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

The SPOP gene, which encodes an E3 ubiquitin ligase adaptor, is frequently mutated in a number of cancer types. However, the mechanisms by which SPOP functions as a tumor suppressor remain poorly understood. Here, we show that SPOP promotes senescence, an important tumor suppression mechanism, by ta...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Hengrui Zhu, Shancheng Ren, Benjamin G. Bitler, Katherine M. Aird, Zhigang Tu, Emmanuel Skordalakes, Yasheng Zhu, Jun Yan, Yinghao Sun, Rugang Zhang
Format:	Article
Language:	English
Published:	Elsevier 2015-11-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715011377