Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

Activation of phosphoinositide 3-kinase (PI3K) and Akt (protein kinase B) is a common response triggered by a range of membrane-bound receptors on many cell types. In T lymphocytes, the PI3K-Akt pathway promotes clonal expansion, differentiation, and survival of effector cells and suppresses the gen...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Takanori eSo, Michael eCroft
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-06-01
Subjects:	Akt TRAF PI3K TNFRSF signalosome TNFSF
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00139/full