Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita

Stress-induced heat shock protein 70 (Hsp70) is a key intra- and extracellular molecular chaperone implicated in autoimmune processes. Highly immunogenic extracellular Hsp70 can activate innate and acquired (adaptive) immune responses driving the generation of anti-Hsp70 autoantibodies that are freq...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	autoimmune bullous diseases (AIBDs) epidermolysis bullosa acquisita (EBA) heat shock proteins (Hsps) Hsp70 autoantibodies nuclear factor kappa B (NF-κB)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.877958/full