Mitochondrial Diseases: Molecular Pathogenesis and Therapeutic Advances

ABSTRACT Mitochondrial diseases are a heterogeneous group of inherited disorders caused by pathogenic variants in mitochondrial DNA (mtDNA) or nuclear genes encoding mitochondrial proteins, culminating in defective oxidative phosphorylation and multisystem involvement. Key pathogenic mechanisms incl...

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Bibliographic Details

Published in:	MedComm
Main Authors:	Jialun Mei, Peng Ding, Chuan Gao, Jian Zhou, Zhiwei Li, Changqing Zhang, Junjie Gao
Format:	Article
Language:	English
Published:	Wiley 2025-09-01
Subjects:	mitochondrial gene editing mitochondrial DNA (mtDNA) gene therapy base editing mitochondrial diseases genetic medicine
Online Access:	https://doi.org/10.1002/mco2.70385