Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats

Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug. This study aimed to address the toxic effects of CP on male fertility and the possible ameliorative role of hesperidin (HSP). Thirty-two adult albino rats were randomly divided into four groups, namely, the n...

Full description

Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Tarek Khamis, Abdelmonem Awad Hegazy, Samaa Salah Abd El-Fatah, Eman Ramadan Abdelfattah, Marwa Mohamed Mahmoud Abdelfattah, Liana Mihaela Fericean, Ahmed Hamed Arisha
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	cyclophosphamide hesperidin apoptosis P53 iNOS oxidative stress
Online Access:	https://www.mdpi.com/1424-8247/16/2/301