Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

Abstract Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types. Activated in response to danger associated molecular patterns (DAMPs) including AT...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Elena Roger, Christos E. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, Chelsy L. Cliff, Safia Hadjadj, Jessy Renciot, Paul E. Squires, Claire E. Hills
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Connexins Connexin 43 Hemichannels Inflammation Inflammasomes Kidney disease
Online Access:	https://doi.org/10.1186/s12964-023-01245-7