Distinct gut microbiome features characterize Fasciola hepatica infection and predict triclabendazole treatment outcomes in Peruvian patients

BackgroundFasciola hepatica, a globally distributed helminth, causes fasciolosis, a disease with significant health and economic impacts. Variability in triclabendazole (TCBZ) efficacy and emerging resistance are remaining challenges. Evidence suggests that the gut microbiome influences host-helmint...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Giljae Lee, Bruce A. Rosa, Martha V. Fernandez-Baca, John Martin, Rodrigo A. Ore, Pedro Ortiz, Miguel M. Cabada, Makedonka Mitreva
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	liver fluke Fasciola hepatica triclabendazole treatment response intestinal microbiome metagenomic shotgun sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1555171/full