Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans

BACKGROUND Most GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODS We conducted a discovery GWAS of approximately 3,000 plasma proteins measured by the antibody-based Olin...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Usman A. Tahir, Jacob L. Barber, Daniel E. Cruz, Meltem Ece Kars, Shuliang Deng, Bjoernar Tuftin, Madeline G. Gillman, Mark D. Benson, Jeremy M. Robbins, Zsu-Zsu Chen, Prashant Rao, Daniel H. Katz, Laurie Farrell, Tamar Sofer, Michael E. Hall, Lynette Ekunwe, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Yii-Der Ida Chen, Ani W. Manichaikul, Deepti Jain, NHLBI Trans-Omics for Precision Medicine Consortium, Thomas J. Wang, Alex P. Reiner, Pradeep Natarajan, Yuval Itan, Stephen S. Rich, Jerome I. Rotter, James G. Wilson, Laura M. Raffield, Robert E. Gerszten
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-11-01
Subjects:	Genetics Immunology
Online Access:	https://doi.org/10.1172/JCI181802