Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity

Abstract Exercise promotes brain plasticity partly by stimulating increases in mature brain-derived neurotrophic factor (mBDNF), but the role of the pro-BDNF isoform in the regulation of BDNF metabolism in humans is unknown. We quantified the expression of pro-BDNF and mBDNF in human skeletal muscle...

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Bibliographic Details

Published in:	Function
Main Authors:	Sebastian Edman, Oscar Horwath, Thibaux Van der Stede, Sarah Joan Blackwood, Isabel Moberg, Henrik Strömlind, Fabian Nordström, Maria Ekblom, Abram Katz, William Apró, Marcus Moberg
Format:	Article
Language:	English
Published:	American Physiological Society 2024-01-01
Subjects:	neurotrophins exercise muscle fiber type lactate β-hydroxybutyrate fasting
Online Access:	https://journals.physiology.org/doi/10.1093/function/zqae005