The Role of Trifluoromethyl and Trifluoromethoxy Groups in Medicinal Chemistry: Implications for Drug Design

One of the key strategies in drug design involves modifying molecular scaffolds with specific chemical groups, or side chains, to enhance biological and physicochemical properties. These modifications can strengthen interactions with biological targets or improve pharmacokinetic and physicochemical...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Manuel Novás, Maria J. Matos
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Subjects:	trifluoromethyl group trifluoromethoxy group drug design medicinal chemistry
Online Access:	https://www.mdpi.com/1420-3049/30/14/3009