Evaluation of the clinical use of MGMT methylation in extracellular vesicle-based liquid biopsy as a tool for glioblastoma patient management

Abstract Glioblastoma (GB) is a devastating tumor of the central nervous system characterized by a poor prognosis. One of the best-established predictive biomarker in IDH-wildtype GB is O6-methylguanine-DNA methyltransferase (MGMT) methylation (mMGMT), which is associated with improved treatment res...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Rocío Rosas-Alonso, Julian Colmenarejo-Fernández, Olga Pernía, Miranda Burdiel, Carlos Rodríguez-Antolín, Itsaso Losantos-García, Tania Rubio, Rocío Moreno-Velasco, Isabel Esteban-Rodríguez, Virginia Martínez-Marín, Paloma Yubero, Nicolas Costa-Fraga, Angel Díaz-Lagares, Rafael López-López, Eva Díaz-Martin, Juan F. García, Catalina Vivancos Sánchez, Maria Luisa Gandía-González, Gema Moreno-Bueno, Javier de Castro, Inmaculada Ibánez de Cáceres
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Subjects:	Small extracellular vesicles (sEVs) MGMT Methylation Glioblastoma Liquid biopsy
Online Access:	https://doi.org/10.1038/s41598-024-62061-8