FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum‐Selective Autophagy in Cardiomyocytes

Background Cardiomyocytes require the HSP70 (heat shock protein 70) chaperone BiP (binding immunoglobulin protein) to maintain proteostasis in the endoplasmic reticulum (ER) following cardiac stress. The adenylyl transferase FICD (FIC domain protein adenylyl transferase) is increasingly recognized t...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. Truttmann
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Subjects:	BiP ER FICD hypertrophy proteostasis
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040192