Sex differences in the therapeutic effect of unaltered versus NFκB sensing IL-4 over-expressing mesenchymal stromal cells in a murine model of chronic inflammatory bone loss

Wear particles from joint arthroplasties induce chronic inflammation associated with prolonged upregulation of nuclear factor kappa-B (NF-κB) signaling in macrophages and osteoclasts, which leads to osteolysis and implant loosening. Mesenchymal stromal cell (MSC)-based therapy showed great potential...

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发表在:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Huaishuang Shen, Junichi Kushioka, Masakazu Toya, Takeshi Utsunomiya, Hirohito Hirata, Ejun Elijah Huang, Masanori Tsubosaka, Qi Gao, Xueping Li, Victoria Teissier, Ning Zhang, Stuart B. Goodman
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2022-08-01
主题:	sex differences chronic inflammatory bone loss wear particles mesenchymal stromal cell macrophage
在线阅读:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.962114/full