Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis

Abstract Background The cell cycle of mammary stem cells must be tightly regulated to ensure normal homeostasis of the mammary gland to prevent abnormal proliferation and susceptibility to tumorigenesis. The atypical cell cycle regulator, Spy1 can override cell cycle checkpoints, including those act...

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Bibliographic Details

Published in:	Breast Cancer Research
Main Authors:	Bre-Anne Fifield, John Vusich, Erika Haberfellner, Eran R. Andrechek, Lisa A. Porter
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Mammary stem cells Cell cycle Mammary gland development Breast cancer Breast cancer stem cells
Online Access:	https://doi.org/10.1186/s13058-024-01862-1