A Novel Star Like Eight-Arm Polyethylene Glycol-Deferoxamine Conjugate for Iron Overload Therapy

The traditional iron chelator deferoxamine (DFO) has been widely used in the treatment of iron overload disease. However, DFO has congenital disadvantages, including a very short circular time and non-negligible toxicity. Herein, we designed a novel multi-arm conjugate for prolonging DFO duration in...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Bohong Yu, Yinxian Yang, Qi Liu, Aiyan Zhan, Yang Yang, Hongzhuo Liu
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	8-arm-polyethylene glycol deferoxamine conjugation chelator cytotoxicity half-life
Online Access:	https://www.mdpi.com/1999-4923/12/4/329