Synthesis and anticancer evaluation of diaryl pyrido[2,3-d]pyrimidine /alkyl substituted pyrido[2,3-d]pyrimidine derivatives as thymidylate synthase inhibitors

Abstract Worldwide, colorectal cancer (CRC) is the third most common type of cancer and the second most common cause of cancer-related deaths. Thymidylate synthase (TS) is a crucial component of DNA biosynthesis and has drawn interest as an essential target for cancer treatment. In the current work,...

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Bibliographic Details

Published in:	BMC Chemistry
Main Authors:	Adarsh Kumar, Nabeel Backer, Harshali Paliwal, Ankit Kumar Singh, Tanushree Debbaraman, Vikramjeet Singh, Pradeep Kumar
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Colorectal cancer Pyrido[2,3-d]pyrimidine Thymidylate synthase Anticancer In silico studies
Online Access:	https://doi.org/10.1186/s13065-024-01228-w