Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice

Microglia-mediated chronic neuroinflammation has been associated with cognitive decline induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the mechanisms remain unclear. This work aimed to elucidate the role of complement receptor 3 (CR3), a highly expressed recepto...

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Bibliographic Details

Published in:	Ecotoxicology and Environmental Safety
Main Authors:	Qinghui Wang, Zhengzheng Ruan, Lu Jing, Ziyang Guo, Xiaomeng Zhang, Jianing Liu, Lu Tian, Wei Sun, Sheng Song, Jau-Shyong Hong, Yen-Yu Ian Shih, Liyan Hou, Qingshan Wang
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Microglia Neuroinflammation Complement receptor 3 Cognitive deficit Parkinson’s disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651323010540