Aqueous extract of Platycodon grandiflorus attenuates lipopolysaccharide-induced apoptosis and inflammatory cell infiltration in mouse lungs by inhibiting PI3K/Akt signaling

Abstract Background Acute lung injury (ALI), an acute inflammatory lung disease, can cause a rapid inflammatory response in clinic, which endangers the patient's life. The components of platycodon grandiflorum, such as platycodins have a wide range of pharmacological activities such as expector...

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Published in:	Chinese Medicine
Main Authors:	Yang Zhou, Tianzi Jin, Mingtong Gao, Zichen Luo, Sadaf Mutahir, Chen Shi, Tong Xie, Lili Lin, Jianya Xu, Yingzhao Liao, Ming Chen, Haishan Deng, Min Zheng, Jinjun Shan
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Acute lung injury Aqueous extract of Platycodon grandiflorus Lipidomics Network pharmacology PI3K/Akt signaling pathway
Online Access:	https://doi.org/10.1186/s13020-023-00721-z