Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency

Abstract Background Epigenetic modifications, nucleosome occupancy, and three-dimensional chromatin architecture collectively create a multi-layered, highly interactive regulatory system for controlling genomic functionality. Dysregulation of epigenetic processes leads to a plethora of abnormalities...

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Bibliographic Details

Published in:	Epigenetics & Chromatin
Main Authors:	Vrinda Venu, Eric M. Small, Cullen Roth, Samantha H. Adikari, Anna Hendrika Cornelia Vlot, Kyle A. Sullivan, Chanaka Roshan Abeyratne, Daniel Jacobson, Shawn R. Starkenburg, Karissa Y. Sanbonmatsu, Christina R. Steadman
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Multiscale chromatin organization Chromatin architecture Chromatin accessibility Transcriptional dynamics Functional epigenomics Histone acetylation
Online Access:	https://doi.org/10.1186/s13072-025-00631-4