Intranasal inoculation of IFN-λ resolves SARS-CoV-2 lung infection via the rapid reduction of viral burden and improvement of tissue damage

IntroductionThe innate immune responses of upper airway could further our understanding toward antiviral strategies against SARS-CoV-2. We characterize the potential of interferon (IFN)-λ as an innate immune inducer for the rapid clearance of SARS-CoV-2 in the lung and the therapeutic efficacy of in...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Haeun Shin, Sujin Kim, Ara Jo, Jina Won, Chan Hee Gil, So Yeon Yoon, Hyunkyung Cha, Hyun Jik Kim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	SARS-CoV-2 interferon-lambda intranasal inoculation viral clearance lung remodeling
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009424/full