5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

Clks have been shown by recent studies to be promising targets for cancer therapy, as they are considered key regulators in the process of pre-mRNA splicing, which in turn affects every aspect of tumor biology. In particular, Clk1 and -4 are overexpressed in several human tumors. Most of the potent...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Molecules
المؤلفون الرئيسيون: Ahmed K. ElHady, Dalia S. El-Gamil, Po-Jen Chen, Tsong-Long Hwang, Ashraf H. Abadi, Mohammad Abdel-Halim, Matthias Engel
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2021-02-01
الموضوعات:
Clk1 inhibitor
pre-mRNA splicing
anticancer
الوصول للمادة أونلاين:https://www.mdpi.com/1420-3049/26/4/1001

الانترنت

https://www.mdpi.com/1420-3049/26/4/1001

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