Why do tumor-infiltrating lymphocytes have variable efficacy in the treatment of solid tumors?

Lymphocytes in tumor tissue are called tumor-infiltrating lymphocytes (TILs), and they play a key role in the control and treatment of tumor diseases. Since the discovery in 1987 that cultured TILs can kill tumor cells more than 100 times more effectively than T-cells cultured from peripheral blood...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Author:	Biaoru Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	TILs (tumor infiltrating lymphocytes) solid tumor TIL quiescence TIL attacking heterogeneous antigen TIL infiltration personalized immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.973881/full