Engineered Multivalent Nanobodies Efficiently Neutralize SARS-CoV-2 Omicron Subvariants BA.1, BA.4/5, XBB.1 and BQ.1.1

Most available neutralizing antibodies are ineffective against highly mutated SARS-CoV-2 Omicron subvariants. Therefore, it is crucial to develop potent and broad-spectrum alternatives to effectively manage Omicron subvariants. Here, we constructed a high-diversity nanobody phage display library and...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Jiali Wang, Bingjie Shi, Hanyi Chen, Mengyuan Yu, Peipei Wang, Zhaohui Qian, Keping Hu, Jianxun Wang
Format:	Article
Language:	English
Published:	MDPI AG 2024-04-01
Subjects:	SARS-CoV-2 Omicron subvariants phage display library receptor-binding domain (RBD) multivalent nanobodies neutralizing activity
Online Access:	https://www.mdpi.com/2076-393X/12/4/417