Molecular diagnosis for detecting KRAS mutation in peritoneal washing fluid of pancreatic ductal adenocarcinoma

Abstract Positive peritoneal washing cytology is an indicator of poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC); however, its sensitivity is relatively low. This study evaluated the performance of peptide nucleic acid (PNA)-directed PCR clamping as a molecular-based peritone...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Gaku Shimane, Yutaka Nakano, Sachiko Matsuda, Minoru Kitago, Yohei Masugi, Kohei Nakamura, Yuki Nakamura, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Shutaro Hori, Masayuki Tanaka, Ryo Takemura, Hiroshi Nishihara, Yuko Kitagawa
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Subjects:	KRAS Peritoneal washing fluid Cytology Pancreatic ductal adenocarcinoma
Online Access:	https://doi.org/10.1038/s41598-024-72569-8