Large-scale turnover of functional transcription factor binding sites in Drosophila.

The gain and loss of functional transcription factor binding sites has been proposed as a major source of evolutionary change in cis-regulatory DNA and gene expression. We have developed an evolutionary model to study binding-site turnover that uses multiple sequence alignments to assess the evoluti...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Alan M Moses, Daniel A Pollard, David A Nix, Venky N Iyer, Xiao-Yong Li, Mark D Biggin, Michael B Eisen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2006-10-01
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.0020130&type=printable