Functional selectivity of Receptor Tyrosine Kinases regulates distinct cellular outputs

Functional selectivity refers to the activation of differential signalling and cellular outputs downstream of the same membrane-bound receptor when activated by two or more different ligands. Functional selectivity has been described and extensively studied for G-protein Coupled Receptors (GPCRs), l...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Sakim S. Samad, Jean-Marc Schwartz, Chiara Francavilla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	functional selectivity ligand bias ligand concentration modelling receptor tyrosine kinase (RTK) cell signalling
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1348056/full