A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis

Abstract The lysophosphatidic acid (LPA) signaling axis is an important but rather underexplored pathway in liver disease. LPA is predominantly produced by Autotaxin (ATX) that has gained significant attention with an impressive number of ATX inhibitors (type I‐IV) reported. Here, we evaluated the t...

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發表在:	EMBO Molecular Medicine
Main Authors:	Richell Booijink, Fernando Salgado‐Polo, Craig Jamieson, Anastassis Perrakis, Ruchi Bansal
格式:	Article
語言:	英语
出版:	Springer Nature 2022-07-01
主題:	Autotaxin–lysophosphatidic acid (ATX‐LPA) axis inflammation fibrosis liver disease signaling pathways
在線閱讀:	https://doi.org/10.15252/emmm.202216333