Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice

Abstract Ulcerative colitis (UC) belongs to chronic inflammatory disease with a relapsing characterization. Conventional oral drugs of UC are restricted in clinical by premature degradation in the gastrointestinal tract, modest efficacy, and adverse effects. CX5461 can treat autoimmune disease, immu...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Manqi Zhang, Xichao Xu, Liqian Su, Yuqing Zeng, Jingxiong Lin, Wenwen Li, Yigui Zou, Sicong Li, Boxian Lin, Ziyuan Li, Hu Chen, Yuheng Huang, Quanle Xu, Hongbo Chen, Fang Cheng, Dongling Dai
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Ulcerative colitis Sophora Flavescens-derived exosomes-like nanovesicles CX5461 Inflammation Macrophage
Online Access:	https://doi.org/10.1186/s12951-024-02856-z