Acute symptomatic seizure prevention with perampanel in moderate and severe traumatic brain injury: a retrospective comparison with levetiracetam

BackgroundAcute symptomatic seizures (ASS) occurring within 7 days after traumatic brain injury (TBI) may exacerbate secondary brain injury via excitotoxicity and elevated intracranial pressure. They are also risk factors for post-traumatic epilepsy (PTE). However, the optimal anti-seizure medicatio...

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Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Junzo Nakao, Hideki Kashiwagi, Kohei Yoshimura, Akihiro Kambara, Ryusuke Kotera, Kotaro Honda, Yu Amemiya, Junji Hatakeyama, Ken Sakakibara, Kazuma Yamakawa, Shinji Kawabata, Masahiko Wanibuchi, Akira Takasu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	AMPA receptor blockade neuroprotection head trauma secondary brain injury seizure prophylaxis
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1665997/full