Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens

De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge. While focus has been largely on cytotoxic cell-mediated tumor eradication, B-cells and the antibodies they produce als...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Hsuan Su, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Phuong L. Doan, Stefanie Sarantopoulos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	alphavirus replicon particle hematolymphoid tumor B cell tolerance autoantigen antitumor antibody VRP
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.865486/full