DNA demethylating agents suppress preclinical models of synovial sarcoma

Synovial sarcoma is an aggressive soft-tissue cancer driven by the chimeric SS18::SSX fusion oncoprotein, which disrupts chromatin remodeling by combining two antagonistic transcriptional regulators. SS18 participates in BAF complexes that open chromatin, while the SSX genes are cancer-testis antige...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Nobuhiko Hasegawa, Nezha S. Benabdallah, Kyllie Smith-Fry, Li Li, Sarah McCollum, Jinxiu Li, Caelen A. Jones, Lena Wagner, Vineet Dalal, Viola Golde, Anastasija Pejkovska, Lara Carroll, Malay Haldar, Seth M. Pollack, Scott W. Lowe, Torsten O. Nielsen, Ana Banito, Kevin B. Jones
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2025-07-01
Subjects:	Genetics Oncology
Online Access:	https://doi.org/10.1172/JCI190855