Dual Action of Memantine in Alzheimer Disease: A Hypothesis

Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-methyl-d-aspartate receptors in the brain. Re...

Full description

Bibliographic Details
Published in:	Taiwanese Journal of Obstetrics & Gynecology
Main Authors:	Tzong-Yuan Wu, Chih-Ping Chen
Format:	Article
Language:	English
Published:	Elsevier 2009-09-01
Subjects:	Alzheimer disease amyloid-β peptide internal ribosome entry site memantine N-methyl-d-aspartate receptors
Online Access:	http://www.sciencedirect.com/science/article/pii/S102845590960303X

Similar Items

Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications
by: Bin‐Can Tang, et al.
Published: (2023-09-01)

Management of moderate to severe Alzheimer’s disease: Focus on memantine
by: Evangelyn Dominguez, et al.
Published: (2011-12-01)

Memantine-Assisted Treatment of N-Methyl-D-Aspartate Receptor Antibody Encephalitis: A Mini Review
by: Liu FX, et al.
Published: (2024-12-01)

The Effect of Add-on Memantine in New Onset Combat-Related Posttraumatic Stress Disorder Core Symptoms: A Pilot Study
by: Fatemeh Rajabi, et al.
Published: (2023-06-01)

Effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: A potential therapeutic for Alzheimer's disease
by: Oliver B. Villaflores, et al.
Published: (2012-12-01)

Efficacy of memantine premedication in alleviating postoperative pain- A systematic review and meta-analysis
by: Abhijit Nair, et al.
Published: (2024-01-01)

Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease
by: Bakhshwin Duaa M., et al.
Published: (2024-05-01)

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
by: Tapas Kumar Mohapatra, et al.
Published: (2025-06-01)

Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism
by: Masatoshi Ogawa, et al.
Published: (2019-12-01)

Alzheimer’s disease and its treatment–yesterday, today, and tomorrow
by: A. Y. Kim, et al.
Published: (2024-05-01)

The Evaluation of Memantine Effect on Tinnitus Severity
by: Babak Pourayyoubi, et al.
Published: (2025-07-01)

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease
by: Giambattista Marotta, et al.
Published: (2020-09-01)

Acetylcholinesterase inhibitors combined with memantine for moderate to severe Alzheimer's disease: a meta-analysis
by: Dominik Glinz, et al.
Published: (2019-06-01)

A systematic review of economic evaluations of the use of memantine alone or combined with donepezil for moderate to severe Alzheimer’s disease
by: Ione Ayala Gualandi de Oliveira, et al.
Published: (2019-11-01)

Evidence That Memantine Reduces Chronic Tinnitus Caused By Acoustic Trauma In Rats
by: Yiwen eZheng, et al.
Published: (2012-08-01)

A Multicentre, Randomised, Open-Label, Prospective Study to Estimate the Add-On Effects Of Memantine as Ebixa® Oral Pump (Solution) on Language in Patients with Moderate to Severe Alzheimer’s Disease Already Receiving Donepezil (ROMEO-AD)
by: Hee-Jin Kim, et al.
Published: (2023-05-01)

The role of Memantine in slowing cognitive decline in patients with Down syndrome–A systematic review and meta analysis
by: Zarmina Islam, et al.
Published: (2024-03-01)

Effect of memantine on spatial learning and memory in electrical leisions model of nucleus basalis magnocellularis: animal model of Alzheimer’s disease
by: Nastaran Zamani, et al.
Published: (2018-03-01)

A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer’s disease
by: Deardorff WJ, et al.
Published: (2016-10-01)

The Effect of Memantine on the Expression of Dopamine Receptors in the Striatum of Male Rats With Morphine Addiction
by: Sahar Khalili Samani, et al.
Published: (2023-08-01)

Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease
by: Hongtao Du, et al.
Published: (2023-12-01)

Neuroprotective Effect of Quercetin and Memantine against AlCl<sub>3</sub>-Induced Neurotoxicity in Albino Wistar Rats
by: Ratnakar Jadhav, et al.
Published: (2023-01-01)

Effects of Memantine, an NMDA Antagonist, on Metabolic Syndromes in Female NMRI Mice
by: Naser Osanloo, et al.
Published: (2015-10-01)

Effects of Memantine on the Spontaneous Firing Frequency of Hippocampal CA1 Pyramidal Neurons in Intact and Alzheimer Rat Model: An Electrophysiological Study
by: Nastaran Zamani, et al.
Published: (2022-09-01)

In Silico and In Vivo Evaluation of a New Derivative from Memantine and Sinapic Acid (<i>N</i>-Sinapoyl-memantine) as a Candidate for the Management of Alzheimer’s Disease
by: Andrey Popatanasov, et al.
Published: (2025-05-01)

Memantine administration prevented chorea movement in Huntington’s disease: a case report
by: Kazumasa Saigoh, et al.
Published: (2023-10-01)

Effects of CAPAH, memantine, and rivastigmine on behavioral and cognitive functions of rats
by: D. O. Nikitin, et al.
Published: (2024-11-01)

Virtual Therapy with the NMDA Antagonist Memantine in Hippocampal Models of Moderate to Severe Alzheimer’s Disease, in Silico Trials
by: Dariusz Świetlik, et al.
Published: (2022-04-01)

Interactions of memantine and rivastigmine with graphene oxide nanocarrier and beta-amyloid protein using molecular docking and in-silico methods
by: Fateme Davoudi, et al.
Published: (2024-09-01)

Alzheimer's disease under the mask of stroke
by: A. A. Naumenko, et al.
Published: (2016-07-01)

A Comparative Study of the Prescription of Memantine and Piracetam in Poststroke Aphasia
by: Fariborz Khorvash, et al.
Published: (2015-12-01)

Memantine's Role in Refractory Catatonia
by: Jack Mariani, et al.
Published: (2024-11-01)

The Effects of Co-Administration of Memantine And Vitamin D on Spatial Learning and Memory Impairment in Adult Male Rats Model of Alzheimer’s Disease
by: Nastaran Zamani, et al.
Published: (2020-01-01)

Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence
by: Qingmei Cheng, et al.
Published: (2024-09-01)

Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models
by: Nuno Santos Leal, et al.
Published: (2020-11-01)

The Combination of Baicalein and Memantine Reduces Oxidative Stress and Protects against β-amyloid-Induced Alzheimer’s Disease in Rat Model
by: Ratnakar Jadhav, et al.
Published: (2023-03-01)

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
by: Benedikt Kretner, et al.
Published: (2016-03-01)

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease
by: Maria Luisa Moro, et al.
Published: (2018-01-01)

Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions
by: Ou Qiao, et al.
Published: (2021-06-01)

Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer’s Disease Targeting
by: Hasan Turkez, et al.
Published: (2025-02-01)