CD276 enhances sunitinib resistance in clear cell renal cell carcinoma by promoting DNA damage repair and activation of FAK-MAPK signaling pathway

Abstract Objective This study aimed to explore the effect of CD276 expression on the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cell and animal models and the potential mechanisms involved. Methods CD276 expression levels of ccRCC and normal samples were analyzed via online dat...

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Bibliographic Details

Published in:	BMC Cancer
Main Authors:	Zhi-yu Zhang, Jian-hao Xu, Jiang-lei Zhang, Yu-xin Lin, Jun Ou-Yang
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Clear cell renal cell carcinoma Sunitinib CD276 DNA damage repair FAK-MAPK pathway
Online Access:	https://doi.org/10.1186/s12885-024-12402-7