Integrated profiling of semen microbiota and metabolome reveals dysregulation in primary idiopathic male infertility

Abstract Background Primary idiopathic male infertility remains a significant challenge due to its complex etiology and the lack of effective diagnostic tools. This study characterized seminal microbiota and metabolome alterations in this condition and their association with sperm quality, aiming to...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Hailin Yao, Chen Luo, Yang Xian, Bo Liu, Tingting Yang, Run Tian, Xiao Xiao, Wenrui Zhao, Lijuan Ying, Jinyan Xu, Shasha Liu, Yelin Jia, Xuefeng Luo, Dajian Qiu, Yuan Liu, Qinqin Wu, Xiaohong Luo, Zhenmi Liu, Fuping Li
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Infertility Male Semen Microbiota Metabolome Biomarkers
Online Access:	https://doi.org/10.1186/s12967-025-07139-1