Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics

Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disrup...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Megan K. Oliva, Juan José Pérez-Moreno, Jillian O’Shaughnessy, Trevor J. Wardill, Cahir J. O’Kane
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-08-01
Subjects:	hereditary spastic paraplegia endoplasmic reticulum calcium imaging Drosophila neurodegeneration
Online Access:	https://www.frontiersin.org/article/10.3389/fnins.2020.00816/full