Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential

Morphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those with terminal cancer, require high doses of m...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xiangning Zhang, Tingting Jin, Haixia Wang, Shuai Han, Yongxin Liang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-11-01
Subjects:	morphine tolerance microglia signal transduction opioids tolerance mechanisms
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1499799/full