Myosin folding boosts solubility in cardiac muscle sarcomeres
The polymerization of myosin molecules into thick filaments in muscle sarcomeres is essential for cardiac contractility, with the attenuation of interactions between the heads of myosin molecules within the filaments being proposed to result in hypercontractility, as observed in hypertrophic cardiom...
| Published in: | JCI Insight |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical investigation
2024-04-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.178131 |