Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. CNOT3, a subunit of the CCR4-NOT complex, has recently been suggested to be overexpressed in lung cancer and involved in tumor malignancy. However, its precise role and the underlying mechanisms still need to be fully r...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Lin Jing, Meng-En Zhai, Mei-Rui Qian, Yi-Ming Li, Ming-Wei Han, Kun Wang, Wan Huang, Gang Nan, Jian-Li Jiang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-11-01
Online Access:	https://doi.org/10.1038/s41420-023-01701-w