Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

Background & Aims: Hepatocyte transplantation has emerged as a possible treatment option for end-stage liver disease. However, an important obstacle to therapeutic success is the low level of engraftment and proliferation of transplanted hepatocytes, which do not survive long enough to exert...

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Bibliographic Details

Published in:	JHEP Reports
Main Authors:	Mengmeng Jiang, Ren Guo, Yan Ai, Gang Wang, Peilan Tang, Xiaohui Jia, Bingqing He, Qianting Yuan, Xin Xie
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Subjects:	Hepatocyte transplantation Hepatocyte expansion Dedifferentiation Hepatocyte progenitor cells Small molecule compounds
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589555923000010