Role of HLA-I Structural Variants and the Polyreactive Antibodies They Generate in Immune Homeostasis

Cell-surface HLA-I molecules consisting of β2-microglobulin (β2m) associated heavy chains (HCs), referred to as Face-1, primarily present peptides to CD8+ T-cells. HCs consist of three α-domains, with selected amino acid sequences shared by all alleles of all six isoforms. The cell-surface HLA under...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Mepur H. Ravindranath, Fatiha El Hilali, Carly J. Amato-Menker, Hajar El Hilali, Senthamil R. Selvan, Edward J. Filippone
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	HLA-variants epitopes IVIg monoclonal antibodies polyreactive immunostimulation
Online Access:	https://www.mdpi.com/2073-4468/11/3/58