Low-dose xenogeneic mesenchymal stem cells target canine osteoarthritis through systemic immunomodulation and homing

Abstract Background As current therapies for canine osteoarthritis (OA) provide mainly symptomatic improvement and fail to address the complex pathology of the disease, mesenchymal stem cells (MSCs) offer a promising biological approach to address both aspects of OA through their immunomodulatory pr...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Lore Van Hecke, Koen Chiers, Leen Van Brantegem, Gabriele Braun, Klaus Hellmann, Nathalie de Bouvre, Nathalie Van Bruaene, Tine De Ryck, Luc Duchateau, Bernadette Van Ryssen, Kathelijne Peremans, Jimmy H. Saunders, Geert Verhoeven, Glenn Pauwelyn, Jan H. Spaas
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Mesenchymal stem cells Xenogeneic Equine peripheral blood Immunomodulation Homing Osteoarthritis
Online Access:	https://doi.org/10.1186/s13075-023-03168-7