Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor

Abstract Background Atypical teratoid rhabdoid tumors (ATRT) is a rare but aggressive malignancy in the central nervous system, predominantly occurring in early childhood. Despite aggressive treatment, the prognosis of ATRT patients remains poor. RRM2, a subunit of ribonucleotide reductase, has been...

Full description

Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Le Hien Giang, Kuo-Sheng Wu, Wei-Chung Lee, Shing-Shung Chu, Anh Duy Do, Chun A. Changou, Huy Minh Tran, Tsung-Han Hsieh, Hsin-Hung Chen, Chia-Ling Hsieh, Shian-Ying Sung, Alice L. Yu, Yun Yen, Tai-Tong Wong, Che-Chang Chang
Format:	Article
Language:	English
Published:	BMC 2023-12-01
Online Access:	https://doi.org/10.1186/s13046-023-02911-x