Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity

Cisplatin is chemotherapy used for solid tumor treatment like lung, bladder, head and neck, ovarian and testicular cancers. However, cisplatin-induced ototoxicity limits the utility of this agent in cancer patients, especially when dose escalations are needed. Ototoxicity is associated with cochlear...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Raheem F. H. Al Aameri, Entkhab M. A. Alanisi, Adu Oluwatosin, Dheyaa Al Sallami, Sandeep Sheth, Ian Alberts, Shree Patel, Leonard P. Rybak, Vickram Ramkumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Subjects:
Cisplatin
CXCL1
CXCR2
SB225002
Hair cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125948/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125948/full

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