Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT)

Abstract Photodynamic therapy (PDT) is a minimally invasive treatment approved for many types of cancers. PDT involves the administration of photoactive substances called photosensitizers (PS) that selectively accumulate in cancer cells and are subsequently excited/activated by irradiation with ligh...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	5-aminolevulinic acid (5-ALA) Photodynamic therapy (PDT) Cancer stem cells (CSCs) CD133 5-ALA-PDT resistance
Online Access:	https://doi.org/10.1038/s41598-025-88173-3