Computational exploration of molecular flexibility and interaction of meropenem analogs with the active site of oxacillinase-23 in Acinetobacter baumannii

Background: Carbapenem-resistant Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections and is one of the biggest global threats according to the World Health Organization (WHO), particularly causing substantial morbidity and mortality.Objectives: This study aimed...

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发表在:	Frontiers in Chemistry
Main Authors:	Balajee Ramachandran, Saravanan Muthupandian, Jeyakanthan Jeyaraman, Bruno Silvester Lopes
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2023-02-01
主题:	Acinetobacter baumannii beta-lactamases oxacillinase OXA-23 OXA-23 variants meropenem
在线阅读:	https://www.frontiersin.org/articles/10.3389/fchem.2023.1090630/full