Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig

Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vivo expansion of human hepatocytes. Here we report...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Heng Zhao, Weijian Ye, Jianxiong Guo, Jiaoxiang Wang, Deling Jiao, Kaixiang Xu, Chang Yang, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Jie Cai, Tien Dat Nguyen, Yubo Qing, Wenmin Cheng, Baoyu Jia, Honghui Li, Hong-Ye Zhao, Qingfeng Chen, Hong-Jiang Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	immunodeficient pig liver damage RAG2 IL2Rγ FAH
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.950194/full