Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection.

The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessible to SARS-CoV-2. Blocking the proteases prevents...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Pranesh Padmanabhan, Rajat Desikan, Narendra M Dixit
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-12-01
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008461&type=printable