TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

Abstract Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neuron subset, controls severity and progression of e...

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Geoffrey Paltser, Xue Jun Liu, Jason Yantha, Shawn Winer, Hubert Tsui, Ping Wu, Yuko Maezawa, Lindsay S. Cahill, Christine L. Laliberté, Sreeram V. Ramagopalan, Gabriele C. DeLuca, A. Dessa Sadovnick, Igor Astsaturov, George C. Ebers, R. Mark Henkelman, Michael W. Salter, H.-Michael Dosch
Format:	Article
Language:	English
Published:	BMC 2013-05-01
Subjects:	Transient Receptor Potential Vanilloid (TRPV1) Experimental Autoimmune Encephalomyelitis TRPV1 Activation Blood-spinal Cord Barrier (BSCB) TRPV1 Expression
Online Access:	https://doi.org/10.2119/molmed.2012.00329