Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

Human intestinal organoids (HIOs) are a tissue culture model in which small intestine-like tissue is generated from pluripotent stem cells. By carrying out unsupervised hierarchical clustering of RNA-sequencing data, we demonstrate that HIOs most closely resemble human fetal intestine. We observed t...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Stacy R. Finkbeiner, David R. Hill, Christopher H. Altheim, Priya H. Dedhia, Matthew J. Taylor, Yu-Hwai Tsai, Alana M. Chin, Maxime M. Mahe, Carey L. Watson, Jennifer J. Freeman, Roy Nattiv, Matthew Thomson, Ophir D. Klein, Noah F. Shroyer, Michael A. Helmrath, Daniel H. Teitelbaum, Peter J. Dempsey, Jason R. Spence
Format:	Article
Language:	English
Published:	Elsevier 2015-06-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671115001228