Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

β-Lactam antibiotics are the most important and widely used antibacterial agents across the world. However, the widespread dissemination of β-lactamases among pathogenic bacteria limits the efficacy of β-lactam antibiotics. This has created a major public health crisis. The use of β-lactamase inhibi...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zhuoran Zhao, Xiayu Shen, Shuang Chen, Jing Gu, Haun Wang, Maria F Mojica, Moumita Samanta, Debsindhu Bhowmik, Alejandro J Vila, Robert A Bonomo, Shozeb Haider
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-02-01
Subjects:	Stenotrophomonas maltophilia L1 metallo-β-lactamase β-lactam antibiotics anti-bacterial resistance molecular dynamics deep learning
Online Access:	https://elifesciences.org/articles/83928